About: Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor

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About: Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor
Creator	Bergmeier, Stephen Courreges, Maria Courreges, S Goetz, Douglas Goetz, K »more»
source	Elsevier; Medline; PMC
abstract	Sepsis is a serious condition that can lead to long-term organ damage and death. At the molecular level, the hallmark of sepsis is the elevated expression of a multitude of potent cytokines, i.e. a cytokine storm. For sepsis involving gram-negative bacteria, macrophages recognize lipopolysaccharide (LPS) shed from the bacteria, activating Toll-like-receptor 4 (TLR4), and triggering a cytokine storm. Glycogen synthase kinase-3 (GSK-3) is a highly active kinase that has been implicated in LPS-induced cytokine production. Thus, compounds that inhibit GSK-3 could be potential therapeutics for sepsis. Our group has recently described a novel and highly selective inhibitor of GSK-3 termed COB-187. In the present study, using THP-1 macrophages, we evaluated the ability of COB-187 to attenuate LPS-induced cytokine production. We found that COB-187 significantly reduced, at the protein and mRNA levels, cytokines induced by LPS (e.g. IL-6, TNF-α, IL-1β, CXCL10, and IFN-β). Further, the data suggest that the inhibition could be due, at least in part, to COB-187 reducing NF-κB (p65/p50) DNA binding activity as well as reducing IRF-3 phosphorylation at Serine 396. Thus, COB-187 appears to be a potent inhibitor of the cytokine storm induced by LPS.
has issue date	2020-07-04(xsd:dateTime)
bibo:doi	10.1016/j.ejphar.2020.173340
bibo:pmid	32634441
has license	no-cc
sha1sum (hex)	927f05006957d1d526d0ff544e0bbd644bba28ca
schema:url	https://doi.org/10.1016/j.ejphar.2020.173340
resource representing a document's title	Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor
has PubMed Central identifier	PMC7334664
has PubMed identifier	32634441
schema:publication	Eur J Pharmacol
resource representing a document's body	covid:927f05006957d1d526d0ff544e0bbd644bba28ca#body_text
is schema:about of	named entity 'cytokines' named entity 'binding' named entity 'activating' named entity 'lipopolysaccharide' named entity 'mRNA' »more»

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