About: Human respiratory syncytial virus in children with lower respiratory tract infections or influenza-like illness and its co-infection characteristics with viruses and atypical bacteria in Hangzhou, China

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About: Human respiratory syncytial virus in children with lower respiratory tract infections or influenza-like illness and its co-infection characteristics with viruses and atypical bacteria in Hangzhou, China Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human respiratory syncytial virus in children with lower respiratory tract infections or influenza-like illness and its co-infection characteristics with viruses and atypical bacteria in Hangzhou, China
Creator	Li, Jun Kou, Yu Yang, Xuhui Yu, Xinfen He, Xiaoyan »more»
source	Elsevier; Medline; PMC
abstract	Abstract Background Human respiratory syncytial virus (RSV) is the most important viral pathogen in children. However, its epidemic patterns and co-infection characteristics are not fully understood. Objectives We attempted to determine the level of genetic variation of RSV, and describe the prevalence and co-infection characteristics of RSV in Hangzhou during two epidemic seasons. Study design Single respiratory samples from 1820 pediatric patients were screened for RSV and genotyped by RT-PCR and sequencing. In all RSV positive specimens, we screened for viruses and atypical bacteria. Demographic and clinical information was recorded and analyzed. Results A total of 34.5% and 3.8% of samples from acute lower respiratory tract infections (ALRI) and influenza-like illness (ILI) were positive for RSV, respectively. Phylogenetic analysis revealed that 61.1% of the selected 167 RSV strains were NA1, 31.1% were BA, 3.6% were ON1, 2.4% were CB1, and 1.8% were NA3. A new genotype, BA11 was identified, which comprised 98.1% of BA strains in this study, while the rest were BA10. A total of 36.4% and 9.1% of RSV-positive children with ALRI and ILI respectively were found to be co-infected. Rhinovirus was the most common additional respiratory virus, followed by human metapneumovirus. Except for fever, no significant differences in other clinical presentation between the RSV mono-infection and co-infection groups were observed. Conclusions The circulating RSV strains had high genetic variability with RSV-B showing a more local pattern. In ALRI cases, co-infection of RSV with other viruses or atypical bacteria has no significant effect on the clinical presentation except fever.
has issue date	2015-08-31(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2015.05.015
bibo:pmid	26209367
has license	els-covid
sha1sum (hex)	8df049d1dd965c6ffa5c9bd7f65e655dabd4fa27
schema:url	https://doi.org/10.1016/j.jcv.2015.05.015
resource representing a document's title	Human respiratory syncytial virus in children with lower respiratory tract infections or influenza-like illness and its co-infection characteristics with viruses and atypical bacteria in Hangzhou, China
has PubMed Central identifier	PMC7185398
has PubMed identifier	26209367
schema:publication	Journal of Clinical Virology
resource representing a document's body	covid:8df049d1dd965c6ffa5c9bd7f65e655dabd4fa27#body_text
is schema:about of	named entity 'pathogen' named entity 'Human respiratory syncytial virus' named entity 'strains' named entity 'total' named entity 'co-infected' »more»

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