About: Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction

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About: Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction
Creator	Mourier, Tobias Pain, Arnab Guan, Qingtian Sadykov, Mukhtar
source	BioRxiv
abstract	RNA viruses use CpG reduction to evade the host cell defense, but the driving mechanisms are still largely unknown. In an attempt to address this we used a rapidly growing genomic dataset of SARS-CoV-2 with relevant metadata information. Remarkably, by simply ordering SARS-CoV-2 genomes by their date of collection, we find a progressive increase of C-to-U substitutions resulting in 5’-UCG-3’ motif reduction that in turn have reduced the CpG frequency over just a few months of observation. This is consistent with APOBEC-mediated RNA editing resulting in CpG reduction, thus allowing the virus to escape ZAP-mediated RNA degradation. Our results thus link the dynamics of target sequences in the viral genome for two known host molecular defense mechanisms, mediated by the APOBEC and ZAP proteins.
has issue date	2020-08-07(xsd:dateTime)
bibo:doi	10.1101/2020.06.19.161687
has license	biorxiv
sha1sum (hex)	8c311b5deb1dfc006cd7d5934a6b9a69b386d533
schema:url	https://doi.org/10.1101/2020.06.19.161687
resource representing a document's title	Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction
schema:publication	bioRxiv
resource representing a document's body	covid:8c311b5deb1dfc006cd7d5934a6b9a69b386d533#body_text
is schema:about of	named entity 'Apolipoprotein B' named entity 'sequence motif' named entity 'uracil' named entity 'substitutions' named entity 'finger' »more»

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