About: A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the anti-inflammatory response to the drug tranilast

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About: A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the anti-inflammatory response to the drug tranilast Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the anti-inflammatory response to the drug tranilast
Creator	Hamis, Sara Macfarlane, Fiona
source	ArXiv
abstract	Pyroptosis is an inflammatory mode of cell death that contributes to the cytokine storm associated with severe cases of coronavirus disease 2019 (COVID-19). Central to pyroptosis induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the formation of the NLRP3 inflammasome. Inflammasome formation, and by extension pyroptosis, may be inhibited by certain anti-inflammatory drugs. One such drug, tranilast, is currently being evaluated as a COVID-19 treatment target in a clinical trial. In this study, we present a single-cell mathematical model that captures the formation of the NLRP3 inflammasome, pyroptotic cell death and drug-responses to tranilast. The model is formulated in terms of a system of ordinary differential equations (ODEs) that describe the dynamics of proteins involved in pyroptosis. The model demonstrates that tranilast delays the formation of the NLRP3 inflammasome, and thus may alter the mode of cell death from inflammatory (pyroptosis) to non-inflammatory (e.g., apoptosis).
has issue date	2020-08-10(xsd:dateTime)
has license	arxiv
sha1sum (hex)	8beaeca90fb0370d3698980abadc5665dc312aa5
resource representing a document's title	A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the anti-inflammatory response to the drug tranilast
resource representing a document's body	covid:8beaeca90fb0370d3698980abadc5665dc312aa5#body_text
is schema:about of	named entity 'One' named entity 'Pyroptosis' named entity 'mode' named entity 'induced' covid:arg/8beaeca90fb0370d3698980abadc5665dc312aa5 »more»

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