About: Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines

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About: Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines
Creator	Armengaud, Jean Bellanger, Laurent Cea-Marcoule, Debroas, Stéphanie Gaillard, Jean-Charles »more»
source	BioRxiv
abstract	Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread quickly around the globe. Currently, no effective vaccine is available to prevent COVID-19 and an intense global development activity is in progress. In this context, the different technology platforms face several challenges resulting from the involvement of a new virus still not fully characterised. Finding of the right conditions for virus amplification for the development of vaccines based on inactivated or attenuated whole viral particles is among them. Here, we describe the establishment of a workflow based on shotgun tandem mass spectrometry data to guide the optimisation of the conditions for viral amplification. In parallel, we analysed the dynamic of the host cell proteome following SARS-CoV-2 infection providing a global overview of biological processes modulated by the virus and that could be further explored to identify drug targets to address the pandemic.
has issue date	2020-04-17(xsd:dateTime)
bibo:doi	10.1101/2020.04.17.046193
has license	biorxiv
sha1sum (hex)	8a74fc5cdbc0572785b4de4dd598a2b7447ece00
schema:url	https://doi.org/10.1101/2020.04.17.046193
resource representing a document's title	Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines
schema:publication	bioRxiv
resource representing a document's body	covid:8a74fc5cdbc0572785b4de4dd598a2b7447ece00#body_text
is schema:about of	named entity 'Severe acute respiratory syndrome-related coronavirus' named entity 'continues' named entity 'SARS-CoV-2' named entity 'virus' named entity 'SARS-CoV-2' »more»

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