About: Geographic reconstruction of the SARS-CoV-2 outbreak in Lombardy (Italy) during the early phase

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About: Geographic reconstruction of the SARS-CoV-2 outbreak in Lombardy (Italy) during the early phase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Geographic reconstruction of the SARS-CoV-2 outbreak in Lombardy (Italy) during the early phase
Creator	Bertulli, Barbara Dipaola, Enrica Legnani, Manuela Loiacono, Sara Paola, Vittoria »more»
source	MedRxiv
abstract	The circulation of SARS-CoV-2 in Italy has been dominated by two large clusters of outbreaks in Northern part of the peninsula, source of alarming and prolonged infections in Lombardy region, in Codogno and Bergamo areas especially. The aim of the study was to expand understanding on the circulation of SARS-CoV-2 in the affected Lombardy areas. To this purpose, twenty full length genomes were collected from patients addressing to several Lombard hospitals from February 20th to April 4th, 2020. The obtained genome assemblies, available on the GISAD database and performed at the Referral Center for COVID-19 diagnosis, identified 2 main monophyletic clades, containing 9 and 52 isolates, respectively. The molecular clock analysis estimated a clusters divergence approximately one month before the first patient identification, supporting the hypothesis that different SARS-CoV-2 strains spread all over the world at different time, but their presence became evident only in late February along with Italian epidemic emergence. Therefore, the epidemiological reconstruction carried out by this work highlights multiple inputs of the virus into its initial circulation in Lombardy Region. However, a phylogenetic reconstruction robustness will be improved when other genomic sequences will be available, in order to guarantee a complete epidemiological surveillance.
has issue date	2020-07-24(xsd:dateTime)
bibo:doi	10.1101/2020.07.23.20159871
has license	medrxiv
sha1sum (hex)	8875cdf5c85dfac309b1e2adf713d690b63aaa99
schema:url	https://doi.org/10.1101/2020.07.23.20159871
resource representing a document's title	Geographic reconstruction of the SARS-CoV-2 outbreak in Lombardy (Italy) during the early phase
resource representing a document's body	covid:8875cdf5c85dfac309b1e2adf713d690b63aaa99#body_text
is schema:about of	named entity 'epidemiological surveillance' named entity 'addressing' named entity 'aim' named entity 'Center' named entity 'strains' »more»

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