About: Towards the design of multiepitope-based peptide vaccine candidate against SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Towards the design of multiepitope-based peptide vaccine candidate against SARS-CoV-2
Creator	Abdulhameed Odhar, Hasanain Ahjel, Suhad Humadi, Odhar, Hasanain Salam, Waheed
source	BioRxiv
abstract	Coronavirus disease 2019 is a current pandemic health threat especially for elderly patients with comorbidities. This respiratory disease is caused by a beta coronavirus known as severe acute respiratory syndrome coronavirus 2. The disease can progress into acute respiratory distress syndrome that can be fatal. Currently, no specific drug or vaccine are available to combat this pandemic outbreak. Social distancing and lockdown have been enforced in many places worldwide. The spike protein of coronavirus 2 is essential for viral entry into host target cells via interaction with angiotensin converting enzyme 2. This viral protein is considered a potential target for design and development of a drug or vaccine. Previously, we have reported several potential epitopes on coronavirus 2 spike protein with high antigenicity, low allergenicity and good stability against specified proteases. In the current study, we have constructed and evaluated a peptide vaccine from these potential epitopes by using in silico approach. This construct is predicted to have a protective immunogenicity, low allergenicity and good stability with minor structural flaws in model build. The population coverage of the used T-cells epitopes is believed to be high according to the employed restricted alleles. The vaccine construct can elicit efficient and long-lasting immune response as appeared through simulation analysis. This multiepitope-based peptide vaccine may represent a potential candidate against coronavirus 2. However, further in vitro and in vivo verification are required.
has issue date	2020-07-08(xsd:dateTime)
bibo:doi	10.1101/2020.07.07.186122
has license	biorxiv
sha1sum (hex)	875a2d7d20d486f1644bea4ba3193b6f547195a5
schema:url	https://doi.org/10.1101/2020.07.07.186122
resource representing a document's title	Towards the design of multiepitope-based peptide vaccine candidate against SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:875a2d7d20d486f1644bea4ba3193b6f547195a5#body_text
is schema:about of	named entity 'restricted' named entity 'proteases' named entity 'spike' named entity 'target cells' named entity 'construct' »more»

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