About: Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis

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About: Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis
Creator	Boix, Loreto Bruix, Jordi Fausto, Nelson Paeper, Bryan Proll, Sean »more»
source	Medline; PMC
abstract	BACKGROUND: Little is known at the molecular level concerning the differences and/or similarities between alcohol and hepatitis C virus induced liver disease. Global transcriptional profiling using oligonucleotide microarrays was therefore performed on liver biopsies from patients with cirrhosis caused by either chronic alcohol consumption or chronic hepatitis C virus (HCV). RESULTS: Global gene expression patterns varied significantly depending upon etiology of liver disease, with a greater number of differentially regulated genes seen in HCV-infected patients. Many of the gene expression changes specifically observed in HCV-infected cirrhotic livers were expectedly associated with activation of the innate antiviral immune response. We also compared severity (CTP class) of cirrhosis for each etiology and identified gene expression patterns that differentiated ethanol-induced cirrhosis by class. CTP class A ethanol-cirrhotic livers showed unique expression patterns for genes implicated in the inflammatory response, including those related to macrophage activation and migration, as well as lipid metabolism and oxidative stress genes. CONCLUSION: Stages of liver cirrhosis could be differentiated based on gene expression patterns in ethanol-induced, but not HCV-induced, disease. In addition to genes specifically regulating the innate antiviral immune response, mechanisms responsible for differentiating chronic liver damage due to HCV or ethanol may be closely related to regulation of lipid metabolism and to effects of macrophage activation on deposition of extracellular matrix components.
has issue date	2006-11-22(xsd:dateTime)
bibo:doi	10.1186/1743-422x-3-98
bibo:pmid	17121680
has license	cc-by
sha1sum (hex)	86fe00ed292aab3fd191a7f8253d33dad3be59b3
schema:url	https://doi.org/10.1186/1743-422x-3-98
resource representing a document's title	Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis
has PubMed Central identifier	PMC1676004
has PubMed identifier	17121680
schema:publication	Virol J
resource representing a document's body	covid:86fe00ed292aab3fd191a7f8253d33dad3be59b3#body_text
is schema:about of	named entity 'INDUCED' named entity 'responses' covid:arg/86fe00ed292aab3fd191a7f8253d33dad3be59b3 named entity 'VIROLOGY' named entity 'ALCOHOL' »more»

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