About: SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

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About: SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
Creator	Bartenschlager, Ralf Cortese, Mirko Lee, Ji-Young Neufeldt, Christopher Binder, Marco »more»
source	BioRxiv
abstract	SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, individuals develop severe symptoms that can lead to permanent lung damage or death. These severe cases are often associated with high levels of pro-inflammatory cytokines and low antiviral responses which can lead to systemic complications. We have evaluated transcriptional and cytokine secretion profiles from infected cell cultures and detected a distinct upregulation of inflammatory cytokines that parallels samples taken from infected patients. Building on these observations, we found a specific activation of NF-κB and a block of IRF3 nuclear translocation in SARS-CoV-2 infected cells. This NF-κB response is mediated by cGAS-STING activation and could be attenuated through STING targeting drugs. Our results show that SARS-CoV-2 curates a cGAS-STING mediated NF-κB driven inflammatory immune response in epithelial cells that likely contributes to inflammatory responses seen in patients and might be a target to suppress severe disease symptoms.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1101/2020.07.21.212639
has license	biorxiv
sha1sum (hex)	86f6646d3ad9776d1b58fe1894f69df7534baf93
schema:url	https://doi.org/10.1101/2020.07.21.212639
resource representing a document's title	SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
schema:publication	bioRxiv
resource representing a document's body	covid:86f6646d3ad9776d1b58fe1894f69df7534baf93#body_text
is schema:about of	named entity 'proportion' named entity 'infected' named entity 'driven' named entity 'targeting' named entity 'symptoms' »more»

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