About: Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis

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About: Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis
Creator	Pappalardo, Francesco Pennisi, Marzio Rajput, Abdul-Mateen Toldo, Luca
source	Medline; PMC
abstract	BACKGROUND: Multiple sclerosis (MS) is a disease of central nervous system that causes the removal of fatty myelin sheath from axons of the brain and spinal cord. Autoimmunity plays an important role in this pathology outcome and body's own immune system attacks on the myelin sheath causing the damage. The etiology of the disease is partially understood and the response to treatment cannot easily be predicted. RESULTS: We presented the results obtained using 8 genetically predisposed randomly chosen individuals reproducing both the absence and presence of malfunctions of the Teff-Treg cross-balancing mechanisms at a local level. For simulating the absence of a local malfunction we supposed that both Teff and Treg populations had similar maximum duplication rates. Results presented here suggest that presence of a genetic predisposition is not always a sufficient condition for developing the disease. Other conditions such as a breakdown of the mechanisms that regulate and allow peripheral tolerance should be involved. CONCLUSIONS: The presented model allows to capture the essential dynamics of relapsing-remitting MS despite its simplicity. It gave useful insights that support the hypothesis of a breakdown of Teff-Treg cross balancing mechanisms.
has issue date	2013-10-22(xsd:dateTime)
bibo:doi	10.1186/1471-2105-14-s16-s9
bibo:pmid	24564794
has license	cc-by
sha1sum (hex)	864336d3d1a34686efdd078534a092fc888c2c3f
schema:url	https://doi.org/10.1186/1471-2105-14-s16-s9
resource representing a document's title	Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis
has PubMed Central identifier	PMC3853330
has PubMed identifier	24564794
schema:publication	BMC Bioinformatics
resource representing a document's body	covid:864336d3d1a34686efdd078534a092fc888c2c3f#body_text
is schema:about of	named entity 'sufficient condition' named entity 'presence' named entity 'genetic predisposition' named entity 'Teff' named entity 'multiple sclerosis' »more»

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