About: Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo

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About: Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo
Creator	Yang, Yu Wang, Bin Li, Quanxiao Wu, Daocheng Yang, Xiumei »more»
source	PMC
abstract	A safe and effective vaccine adjuvant is important in modern vaccines. Various Chinese herbal polysaccharides can activate the immune system. Cistanche deserticola (CD) is a traditional Chinese herb and an adjuvant candidate. Here, we confirmed that water-extractable polysaccharides of CD (WPCD) could modulate immune responses in vitro and in vivo. In a dose-dependent manner, WPCD significantly promoted the maturation and function of murine marrow-derived dendritic cells (BM-DCs) through up-regulating the expression levels of MHC-II, CD86, CD80, and CD40, allogenic T cell proliferation, and the yields of IL-12 and TNF-α via toll-like receptor4 (TLR4), as indicated by in vitro experiments. In addition, its immunomodulatory activity was also observed in mice. WPCD effectively improved the titers of IgG, IgG(1) and IgG(2a) and markedly enhanced the proliferation of T and B cells, the production of IFN-γ and IL-4 in CD4(+) T cells and the expression level of IFN-γ in CD8(+) T cells better than Alum. Furthermore, WPCD could markedly up-regulate the expression levels of CD40 and CD80 on DCs in spleen and down-regulate the Treg frequency. The study suggests that polysaccharides of Cistanche deserticola are a safe and effective vaccine adjuvant for eliciting both humoral immunity and cellular immunity by activating DCs via TLR4 signaling pathway.
has issue date	2018-01-23(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0191356
bibo:pmid	29360858
has license	cc-by
sha1sum (hex)	85d7376aca04b7df9b23618734948c2814ccfe19
schema:url	https://doi.org/10.1371/journal.pone.0191356
resource representing a document's title	Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo
has PubMed Central identifier	PMC5779666
has PubMed identifier	29360858
schema:publication	PLoS One
resource representing a document's body	covid:85d7376aca04b7df9b23618734948c2814ccfe19#body_text
is schema:about of	named entity 'CISTANCHE DESERTICOLA' named entity 'titers' named entity 'vivo' named entity 'T cells' named entity 'TLR4' »more»

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