About: Genetic characterization of commensal Escherichia coli isolated from laboratory rodents

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic characterization of commensal Escherichia coli isolated from laboratory rodents
Creator	Wong, Pooi-Fong Abubakar, Sazaly Amir, Syahar Asma, Nurul Azura, Haryanti »more»
source	Medline; PMC
abstract	BACKGROUND: Escherichia coli, a commensal in the intestines of vertebrates, is capable of colonizing many different hosts and the environment. Commensal E. coli strains are believed to be the precursor of pathogenic strains by means of acquisition of antimicrobial resistant and virulence genes. Laboratory rodents are inherently susceptible to numerous known infectious agents, which could transfer virulence determinants to commensal E. coli. Hence, in this study, the genetic structure of commensal E. coli found in laboratory rodents and their antimicrobial resistance profiles were investigated. RESULTS: E. coli strains belonging to phylogroup A were the predominant strain obtained from the animals used in the study. Four novel sequence types (ST746, ST747, ST748 and ST749) were discovered using the multi locus sequence typing, together with one common ST357 in the gastrointestinal tract, liver and, the trachea and lung. Serotyping demonstrated that these commensal E. coli strains were non-Shiga toxin-producers. Phenotypic and genotypic analyses of extended spectrum beta lactamases were also negative. CONCLUSIONS: These findings implied that the E. coli strains recovered from the laboratory rodents were truly commensal in nature. Further study is required to investigate the possible influence of gender on the susceptibility of hosts to E. coli colonization in laboratory rodents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40064-016-2745-9) contains supplementary material, which is available to authorized users.
has issue date	2016-07-11(xsd:dateTime)
bibo:doi	10.1186/s40064-016-2745-9
bibo:pmid	27462483
has license	cc-by
sha1sum (hex)	84bb5b317c837c22b090bc10357a3542f58402bd
schema:url	https://doi.org/10.1186/s40064-016-2745-9
resource representing a document's title	Genetic characterization of commensal Escherichia coli isolated from laboratory rodents
has PubMed Central identifier	PMC4940358
has PubMed identifier	27462483
schema:publication	Springerplus
resource representing a document's body	covid:84bb5b317c837c22b090bc10357a3542f58402bd#body_text
is schema:about of	named entity 'ESCHERICHIA COLI' named entity 'hosts' named entity 'RODENTS' named entity 'INVESTIGATED' named entity 'STUDY' »more»

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