About: A molecular pore spans the double membrane of the coronavirus replication organelle

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A molecular pore spans the double membrane of the coronavirus replication organelle
Creator	Bárcena, Montserrat Zevenhoven-Dobbe, Jessika Snijder, Eric De Jong, Anja Koster, Abraham »more»
source	BioRxiv
abstract	Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored micro-environment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and mRNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions. Here, using cellular electron cryo-microscopy, we unveiled a molecular pore complex that spans both membranes of the double-membrane vesicle and would allow export of RNA to the cytosol. A hexameric assembly of a large viral transmembrane protein was found to form the core of the crown-shaped complex. This coronavirus-specific structure likely plays a critical role in coronavirus replication and thus constitutes a novel drug target
has issue date	2020-06-25(xsd:dateTime)
bibo:doi	10.1101/2020.06.25.171686
has license	biorxiv
sha1sum (hex)	845899023b02e03fb13f520cea7f297899a3e5f8
schema:url	https://doi.org/10.1101/2020.06.25.171686
resource representing a document's title	A molecular pore spans the double membrane of the coronavirus replication organelle
schema:publication	bioRxiv
resource representing a document's body	covid:845899023b02e03fb13f520cea7f297899a3e5f8#body_text
is schema:about of	named entity 'abundant' named entity 'accumulate' named entity 'cellular' named entity 'coronavirus' named entity 'cell' »more»

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