About: Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies
Creator	Weber, Friedemann Hwang, Woochang Chapman, Kathryn Han, Namshik Harris, Rebecca »more»
source	BioRxiv
abstract	The global outbreak of SARS-CoV-2 necessitates the rapid development of new therapies against COVID-19 infection. Here, we present the identification of 200 approved drugs, appropriate for repurposing against COVID-19. We constructed a SARS-CoV-2-induced protein (SIP) network, based on disease signatures defined by COVID-19 multi-omic datasets(Bojkova et al., 2020; Gordon et al., 2020), and cross-examined these pathways against approved drugs. This analysis identified 200 drugs predicted to target SARS-CoV-2-induced pathways, 40 of which are already in COVID-19 clinical trials(Clinicaltrials.gov, 2020) testifying to the validity of the approach. Using artificial neural network analysis we classified these 200 drugs into 9 distinct pathways, within two overarching mechanisms of action (MoAs): viral replication (130) and immune response (70). A subset of drugs implicated in viral replication were tested in cellular assays and two (proguanil and sulfasalazine) were shown to inhibit replication. This unbiased and validated analysis opens new avenues for the rapid repurposing of approved drugs into clinical trials.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1101/2020.08.24.265496
has license	biorxiv
sha1sum (hex)	82ee806947278b095792266f96cf698cad27136d
schema:url	https://doi.org/10.1101/2020.08.24.265496
resource representing a document's title	Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies
schema:publication	bioRxiv
resource representing a document's body	covid:82ee806947278b095792266f96cf698cad27136d#body_text
is schema:about of	named entity 'based' named entity 'Clinicaltrials.gov' named entity 'sulfasalazine' named entity 'immune response' named entity 'mechanisms' »more»

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