About: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy

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About: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy
Creator	Castelli, Francesco Focà, Emanuele Latronico, Nicola Piva, Simone Beretta, Alessandra »more»
source	Elsevier; Medline; PMC
abstract	PURPOSE: An ongoing pandemic of COVID-19 that started in Hubei, China has resulted in massive strain on the healthcare infrastructure in Lombardy, Italy. The management of these patients is still evolving. MATERIALS AND METHODS: This is a single-center observational cohort study of critically ill patients infected with COVID-19. Bedside clinicians abstracted daily patient data on history, treatment, and short-term course. We describe management and a proposed severity scale for treatment used in this hospital. RESULTS: 44 patients were enrolled; with incomplete information on 11. Of the 33 studied patients, 91% were male, median age 64; 88% were overweight or obese. 45% were hypertensive, 12% had been taking an ACE-inhibitor. Noninvasive ventilation was performed on 39% of patients for part or all or their ICU stay with no provider infection. Most patients received antibiotics for pneumonia. Patients also received lopinivir/ritonavir (82%), hydroxychloroquine (79%), and tocilizumab (12%) according to this treatment algorithm. Nine of 10 patients survived their ICU course and were transferred to the floor, with one dying in the ICU. CONCLUSIONS: ICU patients with COVID-19 frequently have hypertension. Many could be managed with noninvasive ventilation, despite the risk of aerosolization. The use of a severity scale augmented clinician management.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1016/j.jcrc.2020.04.004
bibo:pmid	32330817
has license	no-cc
sha1sum (hex)	80c397cd11a3bcc3ef83acac8da92a4deb8ba208
schema:url	https://doi.org/10.1016/j.jcrc.2020.04.004
resource representing a document's title	Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy
has PubMed Central identifier	PMC7194649
has PubMed identifier	32330817
schema:publication	J Crit Care
resource representing a document's body	covid:80c397cd11a3bcc3ef83acac8da92a4deb8ba208#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'initial' named entity 'infection' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'viral infection' »more»

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