About: A web-based resource for designing therapeutics against Ebola Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A web-based resource for designing therapeutics against Ebola Virus
Creator	Chaudhary, Kumardeep Gupta, Sudheer Kumar Brahmachari, Samir Kumar Dhanda, Sandeep Raghava, Gajendra
source	PMC
abstract	In this study, we describe a web-based resource, developed for assisting the scientific community in designing an effective therapeutics against the Ebola virus. Firstly, we predicted and identified experimentally validated epitopes in each of the antigens/proteins of the five known ebolaviruses. Secondly, we generated all the possible overlapping 9mer peptides from the proteins of ebolaviruses. Thirdly, conserved peptides across all the five ebolaviruses (four human pathogenic species) with no identical sequence in the human proteome, based on 1000 Genomes project, were identified. Finally, we identified peptide or epitope-based vaccine candidates that could activate both the B- and T-cell arms of the immune system. In addition, we also identified efficacious siRNAs against the mRNA transcriptome (absent in human transcriptome) of all the five ebolaviruses. It was observed that three species can potentially be targeted by a single siRNA (19mer) and 75 siRNAs can potentially target at least two species. A web server, EbolaVCR, has been developed that incorporates all the above information and useful computational tools (http://crdd.osdd.net/oscadd/ebola/).
has issue date	2016-04-26(xsd:dateTime)
bibo:doi	10.1038/srep24782
bibo:pmid	27113850
has license	cc-by
sha1sum (hex)	80850d03f16060e460bd50e5622e2196c0622f54
schema:url	https://doi.org/10.1038/srep24782
resource representing a document's title	A web-based resource for designing therapeutics against Ebola Virus
has PubMed Central identifier	PMC4845023
has PubMed identifier	27113850
schema:publication	Sci Rep
resource representing a document's body	covid:80850d03f16060e460bd50e5622e2196c0622f54#body_text
is schema:about of	named entity 'candidates' named entity 'mRNA' named entity 'peptides' named entity 'EBOLA VIRUS' named entity 'EPITOPE' »more»

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