About: In Vitro Cell Death Determination for Drug Discovery: A Landscape Review of Real Issues

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In Vitro Cell Death Determination for Drug Discovery: A Landscape Review of Real Issues
Creator	Lyon, Claude Oullins, France
source	PMC
abstract	Cell death plays a crucial role for a myriad of physiological processes, and several human diseases such as cancer are characterized by its deregulation. There are many methods available for both quantifying and qualifying the accurate process of cell death which occurs. Choosing the right assay tool is essential to generate meaningful data, provide sufficient information for clinical applications, and understand cell death processes. In vitro cell death assays are important steps in the search for new therapies against cancer as the ultimate goal remains the elaboration of drugs that interfere with specific cell death mechanisms. However, choosing a cell viability or cytotoxicity assay among the many available options is a daunting task. Indeed, cell death can be approached by several viewpoints and require a more holistic approach. This review provides an overview of cell death assays usually used in vitro for assessing cell death so as to elaborate new potential chemotherapeutics and discusses considerations for using each assay.
has issue date	2017-02-24(xsd:dateTime)
bibo:doi	10.1177/1179670717691251
bibo:pmid	28469473
has license	cc-by-nc
sha1sum (hex)	80786183397e485664fd049d086f6e3e38ba210f
schema:url	https://doi.org/10.1177/1179670717691251
resource representing a document's title	In Vitro Cell Death Determination for Drug Discovery: A Landscape Review of Real Issues
has PubMed Central identifier	PMC5392044
has PubMed identifier	28469473
schema:publication	J Cell Death
resource representing a document's body	covid:80786183397e485664fd049d086f6e3e38ba210f#body_text
is schema:about of	named entity '2C CELL' named entity 'USED' named entity 'HUMAN DISEASES' named entity 'RIGHT' named entity 'DATA' »more»

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