About: Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons
Creator	Enjuanes, Luis Sola, Isabel Almazán, Fernando Marquez-Jurado, Silvia Zuñiga, Sonia »more»
source	Elsevier; Medline; PMC
abstract	Abstract Coronaviruses (CoVs) infect humans and many animal species, and are associated with respiratory, enteric, hepatic, and central nervous system diseases. The large size of the CoV genome and the instability of some CoV replicase gene sequences during its propagation in bacteria, represent serious obstacles for the development of reverse genetic systems similar to those used for smaller positive sense RNA viruses. To overcome these limitations, several alternatives to more conventional plasmid-based approaches have been established in the last 13 years. In this report, we briefly review and discuss the different reverse genetic systems developed for CoVs, paying special attention to the severe acute respiratory syndrome CoV (SARS-CoV).
has issue date	2014-12-19(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.09.006
bibo:pmid	25261606
has license	els-covid
sha1sum (hex)	7f7147ff48627db0fbec7fe2f55cbded6f0069a9
schema:url	https://doi.org/10.1016/j.virusres.2014.09.006
resource representing a document's title	Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons
has PubMed Central identifier	PMC7114485
has PubMed identifier	25261606
schema:publication	Virus Research
resource representing a document's body	covid:7f7147ff48627db0fbec7fe2f55cbded6f0069a9#body_text
is schema:about of	named entity 'systems' named entity 'diseases' named entity 'viruses' named entity 'positive sense' named entity 'size' »more»

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