About: Mammarenaviral Infection Is Dependent on Directional Exposure to and Release from Polarized Intestinal Epithelia

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About: Mammarenaviral Infection Is Dependent on Directional Exposure to and Release from Polarized Intestinal Epithelia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mammarenaviral Infection Is Dependent on Directional Exposure to and Release from Polarized Intestinal Epithelia
Creator	Lukashevich, Igor Sokoloski, Kevin Beier, Juliane Jokinen, Jenny Warner, Nikole
source	PMC
abstract	Mammarenavirusesare single-stranded RNA viruses with a bisegmented ambisense genome. Ingestion has been shown as a natural route of transmission for both Lassa virus (LASV) and Lymphocytic choriomeningitis virus (LCMV). Due to the mechanism of transmission, epithelial tissues are among the first host cells to come in contact with the viruses, and as such they potentially play a role in spread of virus to naïve hosts. The role of the intestinal epithelia during arenavirus infection remains to be uncharacterized. We have utilized a well-established cell culture model, Caco-2, to investigate the role of intestinal epithelia during intragastric infection. We found that LCMV-Armstrong, LCMV-WE, and Mopeia (MOPV) release infectious progeny via similar patterns. However, the reassortant virus, ML-29, containing the L segment of MOPV and S segment of LASV, exhibits a unique pattern of viral release relative to LCMV and MOPV. Furthermore, we have determined attachment efficacy to Caco-2 cells is potentially responsible for observed replication kinetics of these viruses in a polarized Caco-2 cell model. Collectively, our data shows that viral dissemination and interaction with intestinal epithelia may be host, tissue, and viral specific.
has issue date	2018-02-10(xsd:dateTime)
bibo:doi	10.3390/v10020075
bibo:pmid	29439402
has license	cc-by
sha1sum (hex)	7c693ae9e08e10d9c230c3d00ad7c6612fa13631
schema:url	https://doi.org/10.3390/v10020075
resource representing a document's title	Mammarenaviral Infection Is Dependent on Directional Exposure to and Release from Polarized Intestinal Epithelia
has PubMed Central identifier	PMC5850382
has PubMed identifier	29439402
schema:publication	Viruses
resource representing a document's body	covid:7c693ae9e08e10d9c230c3d00ad7c6612fa13631#body_text
is schema:about of	named entity 'viruses' named entity 'investigate' named entity 'infection' covid:arg/7c693ae9e08e10d9c230c3d00ad7c6612fa13631 named entity 'transmission' »more»

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