About: Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus
Creator	Zitzmann, Nicole Miller, J Miller, Joanna Tyrrell, B Tyrrell, Beatrice »more»
source	Medline; PMC
abstract	The antiviral mechanism of action of iminosugars against many enveloped viruses, including dengue virus (DENV), HIV, influenza and hepatitis C virus, is believed to be mediated by inducing misfolding of viral N-linked glycoproteins through inhibition of host endoplasmic reticulum-resident α-glucosidase enzymes. This leads to reduced secretion and/or infectivity of virions and hence lower viral titres, both in vitro and in vivo. Free oligosaccharide analysis from iminosugar-treated cells shows that antiviral activity correlates with production of mono- and tri-glucosylated sugars, indicative of inhibition of ER α-glucosidases. We demonstrate that glucose-mimicking iminosugars inhibit isolated glycoprotein and glycolipid processing enzymes and that this inhibition also occurs in primary cells treated with these drugs. Galactose-mimicking iminosugars that have been tested do not inhibit glycoprotein processing but do inhibit glycolipid processing, and are not antiviral against DENV. By comparison, the antiviral activity of glucose-mimetic iminosugars that inhibit endoplasmic reticulum-resident α-glucosidases, but not glycolipid processing, demonstrates that inhibition of α-glucosidases is responsible for iminosugar antiviral activity against DENV. This monograph will review the investigations of many researchers into the mechanisms of action of iminosugars and the contribution of our current understanding of these mechanisms for optimising clinical delivery of iminosugars. The effects of iminosugars on enzymes other than glucosidases, the induction of ER stress and viral receptors will be also put into context. Data suggest that inhibition of α-glucosidases results in inhibited release of virus and is the primary antiviral mechanism of action of iminosugars against DENV.
has issue date	2018-05-30(xsd:dateTime)
bibo:doi	10.1007/978-981-10-8727-1_20
bibo:pmid	29845540
has license	no-cc
sha1sum (hex)	7bbe9e4e2d4de9929340530674f08fd7df8eef36
schema:url	https://doi.org/10.1007/978-981-10-8727-1_20
resource representing a document's title	Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus
has PubMed Central identifier	PMC7121742
has PubMed identifier	29845540
schema:publication	Dengue and Zika: Control and Antiviral Treatment Strategies
resource representing a document's body	covid:7bbe9e4e2d4de9929340530674f08fd7df8eef36#body_text
is schema:about of	named entity 'MECHANISMS' named entity 'glycoproteins' named entity 'Antiviral' named entity 'ASSOCIATED' named entity 'GLUCOSIDASES' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software