About: Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin
Creator	Milanetti, Edoardo Miotto, Mattia Rienzo, Lorenzo Ruocco, Giancarlo Boffi, Alberto »more»
source	ArXiv
abstract	Despite the huge effort to contain the infection, the novel SARS-CoV-2 coronavirus has rapidly become pandemics, mainly due to its extremely high human-to-human transmission capability, and a surprisingly high viral charge of symptom-less people. While the seek of a vaccine is still ongoing, promising results have been obtained with antiviral compounds. In particular, lactoferrin is found to have beneficial effects both in preventing and soothing the infection. Here, we explore the possible molecular mechanisms with which lactoferrin interferes with SARS-CoV-2 cell invasion, preventing attachment and/or entry of the virus. To this aim, we search for possible interactions lactoferrin may have with virus structural proteins and host receptors. Representing the molecular iso-electron surface of proteins in terms of 2D-Zernike descriptors, we (i) identified putative regions on the lactoferrin surface able to bind sialic acid receptors on the host cell membrane, sheltering the cell from the virus attachment; (ii) showed that no significant shape complementarity is present between lactoferrin and the ACE2 receptor, while (iii) two high complementarity regions are found on the N- and C-terminal domains of the SARS-CoV-2 spike protein, hinting at a possible competition between lactoferrin and ACE2 for the binding to the spike protein.
has issue date	2020-07-14(xsd:dateTime)
has license	arxiv
sha1sum (hex)	7b6f804f18714d49d5a3b526d80f20067c144355
resource representing a document's title	Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin
resource representing a document's body	covid:7b6f804f18714d49d5a3b526d80f20067c144355#body_text
is schema:about of	named entity 'SARS-COV-2' named entity 'HERE' named entity 'C-TERMINAL' named entity 'HAVE' named entity 'SARS-COV-2' »more»

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