About: Evaluating the diagnostic accuracy of the WHO Severe Acute Respiratory Infection (SARI) criteria in Middle Eastern children under two years over three respiratory seasons

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About: Evaluating the diagnostic accuracy of the WHO Severe Acute Respiratory Infection (SARI) criteria in Middle Eastern children under two years over three respiratory seasons Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evaluating the diagnostic accuracy of the WHO Severe Acute Respiratory Infection (SARI) criteria in Middle Eastern children under two years over three respiratory seasons
Creator	Faouri, Samir Halasa, Natasha Khuri-Bulos, Najwa Shehabi, Asem Piya, Bhinnata »more»
source	Medline; PMC
abstract	OBJECTIVE: The World Health Organization created the Severe Acute Respiratory Infection (SARI) criteria in 2011 to monitor influenza (flu)-related hospitalization. Many studies have since used the SARI case definition as inclusion criteria for surveillance studies. We sought to determine the sensitivity, specificity, positive predictive value, and negative predictive value of the SARI criteria for detecting ten different respiratory viruses in a Middle Eastern pediatric cohort. MATERIALS AND METHODS: The data for this study comes from a prospective acute respiratory surveillance study of hospitalized children <2 years in Amman, Jordan from March 16, 2010 to March 31, 2013. Participants were recruited if they had a fever and/or respiratory symptoms. Nasal and throat swabs were obtained and tested by real-time RT-PCR for eleven viruses. Subjects meeting SARI criteria were determined post-hoc. Sensitivity, specificity, positive predictive value, and negative predictive value of the SARI case definition for detecting ten different viruses were calculated and results were stratified by age. RESULTS: Of the 3,175 patients enrolled, 3,164 were eligible for this study, with a median age of 3.5 months, 60.4% male, and 82% virus-positive (44% RSV and 3.8% flu). The sensitivity and specificity of the SARI criteria for detecting virus-positive patients were 44% and 77.9%, respectively. Sensitivity of SARI criteria for any virus was lowest in children <3 months at 22.4%. Removing fever as a criterion improved the sensitivity by 65.3% for detecting RSV in children <3 months; whereas when cough was removed, the sensitivity improved by 45.5% for detecting flu in same age group. CONCLUSIONS: The SARI criteria have poor sensitivity for detecting RSV, flu, and other respiratory viruses—particularly in children <3 months. Researchers and policy makers should use caution if using the criteria to estimate burden of disease in children.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0232188
bibo:pmid	32353012
has license	cc-by
sha1sum (hex)	7b2e58c9fb494bf80226905af4db48accf619bcc
schema:url	https://doi.org/10.1371/journal.pone.0232188
resource representing a document's title	Evaluating the diagnostic accuracy of the WHO Severe Acute Respiratory Infection (SARI) criteria in Middle Eastern children under two years over three respiratory seasons
has PubMed Central identifier	PMC7192447
has PubMed identifier	32353012
schema:publication	PLoS One
resource representing a document's body	covid:7b2e58c9fb494bf80226905af4db48accf619bcc#body_text
is schema:about of	named entity 'predictive' named entity 'respiratory' named entity 'Sensitivity' named entity 'NEGATIVE PREDICTIVE VALUE' named entity 'Acute Respiratory Infection' »more»

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