About: Comparisons of the genome of SARS-CoV-2 and those of other betacoronaviruses

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About: Comparisons of the genome of SARS-CoV-2 and those of other betacoronaviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparisons of the genome of SARS-CoV-2 and those of other betacoronaviruses
Creator	Gibbs, Adrian Rodríguez-Román, Eduardo
source	BioRxiv
abstract	The genome of SARS-CoV-2 virus causing the worldwide pandemic of COVID-19 is most closely related to viral metagenomes isolated from bats and, more distantly, pangolins. All are of sarbecoviruses of the genus Betacoronavirus. We have unravelled their recombinational and mutational histories. All showed clear evidence of recombination, most events involving the 3’ half of the genomes. The 5’ region of their genomes was mostly recombinant free, and a phylogeny calculated from this region confirmed that SARS-CoV-2 is closer to RmYN02 than RaTG13, and showed that SARS-CoV-2 diverged from RmYN02 at least 26 years ago, and both diverged from RaTG13 at least 37 years ago; recombinant regions specific to these three viruses provided no additional information as they matched no other Genbank sequences closely. Simple pairwise comparisons of genomes show that there are three regions where most non-synonymous changes probably occurred; the DUF3655 region of the nsp3, the S gene and ORF 8 gene. Differences in the last two of those regions have probably resulted from recombinational changes, however differences in the DUF3655 region may have resulted from selection. A hexamer of the proteins encoded by the nsp3 region may form the molecular pore spanning the double membrane of the coronavirus replication organelle (Wolff et al., 2020), and perhaps the acidic polypeptide encoded by DUF3655 lines it, and presents a novel target for pharmaceutical intervention.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.1101/2020.07.12.199521
has license	biorxiv
sha1sum (hex)	7a539696b3b7a770b1fbc808cc0741662f712c1c
schema:url	https://doi.org/10.1101/2020.07.12.199521
resource representing a document's title	Comparisons of the genome of SARS-CoV-2 and those of other betacoronaviruses
schema:publication	bioRxiv
resource representing a document's body	covid:7a539696b3b7a770b1fbc808cc0741662f712c1c#body_text
is schema:about of	named entity 'double' named entity 'genomes' named entity 'nsp3' named entity 'COVID-19' named entity 'genomes' »more»

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