About: An immunohistochemical investigation of porcine epidemic diarrhoea

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About: An immunohistochemical investigation of porcine epidemic diarrhoea Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	An immunohistochemical investigation of porcine epidemic diarrhoea
Creator	Sato, K Iwashita~, K Minami, T Mori~, M Nakazawa, M »more»
source	Elsevier; Medline; PMC
abstract	Summary A sudden outbreak of epidemic diarrhoea of piglets occurred in Japan, the principal features being watery diarrhoea, dehydration and high mortality in newborn animals. The microscopical lesions were villous atrophy in the small intestine, the villous enterocytes being vacuolated and cuboidal in shape. The villus-crypt ratio was severely reduced, varying from 1:1 to 3:1. Transmission electron microscopy showed numerous coronaviruses within the cytoplasm of enterocytes and among microvilli. Specific antigens of porcine epidemic diarrhoea (PED) virus were detected in the cytoplasm of enterocytes by the streptavidin-biotin (SAB) technique. Infected cells, which were most abundant in the villous epithelia of the jejunum and ileum, were present in small numbers in the large intestine, the crypt epithelia, the lamina propria and Peyer's patches. The study suggests that the SAB technique is useful for the diagnosis of PED.
has issue date	1995-07-31(xsd:dateTime)
bibo:doi	10.1016/s0021-9975(05)80069-6
bibo:pmid	7490338
has license	els-covid
sha1sum (hex)	79a53f2ac148a3ee70d11b5d2700b7a42301ada5
schema:url	https://doi.org/10.1016/s0021-9975%2805%2980069-6
resource representing a document's title	An immunohistochemical investigation of porcine epidemic diarrhoea
has PubMed Central identifier	PMC7130422
has PubMed identifier	7490338
schema:publication	Journal of Comparative Pathology
resource representing a document's body	covid:79a53f2ac148a3ee70d11b5d2700b7a42301ada5#body_text
is schema:about of	named entity 'shape' named entity 'numbers' named entity 'Transmission electron microscopy' named entity 'detected' named entity 'Immunohistochemical' »more»

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