About: Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
Creator	Bates, Robert Gnabre, John Huang, Ru
source	Elsevier; Medline; PMC
abstract	Abstract The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North America and the Amerindians from South America. The plant is rich in simple bisphenyl lignans and tricyclic lignans known as cyclolignans. These compounds are responsible for many of the pharmacological activities of extracts of the plants. Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago. Only recently have further studies revealed other crucial activities of the same plant molecules as powerful agents against human immunodeficiency virus, human papillomavirus, cancer, neurodegenerative diseases, and symptoms of aging. Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription. This review summarizes the recent findings on creosote bush lignans. We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies.
has issue date	2015-07-31(xsd:dateTime)
bibo:doi	10.1016/j.jtcme.2014.11.024
bibo:pmid	26151022
has license	els-covid
sha1sum (hex)	791a44c09323dc7a855d86f5c2dfcd6aaf768c8f
schema:url	https://doi.org/10.1016/j.jtcme.2014.11.024
resource representing a document's title	Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
has PubMed Central identifier	PMC4488564
has PubMed identifier	26151022
schema:publication	Journal of Traditional and Complementary Medicine
resource representing a document's body	covid:791a44c09323dc7a855d86f5c2dfcd6aaf768c8f#body_text
is schema:about of	named entity 'prevention' named entity 'Perspectives' named entity 'Creosote bush' named entity 'VIRUSES' named entity 'NORDIHYDROGUAIARETIC ACID' »more»

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