About: Impact of community respiratory viral infections in urban children with asthma

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Impact of community respiratory viral infections in urban children with asthma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impact of community respiratory viral infections in urban children with asthma
Creator	Xmd, X Xphd, X Batterman, Xstuart Brennan, Xsean Comstock, T »more»
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on asthmatic children in the community, particularly in the high-risk urban environment, is less well-defined. OBJECTIVE: We hypothesized that children with high-symptom upper respiratory viral infections have reduced airway function and greater respiratory tract inflammation than children with virus-positive low-symptom illnesses or virus-negative upper respiratory tract symptoms. METHODS: We studied 53 asthmatic children from Detroit, Michigan during scheduled surveillance periods and self-reported respiratory illnesses for one year. Symptom score, spirometry, fraction of exhaled nitric oxide (FeNO) and nasal aspirate biomarkers, viral nucleic acid and rhinovirus (RV) copy number were assessed. RESULTS: Of 658 aspirates collected, 22.9% of surveillance samples and 33.7% of respiratory illnesses were virus-positive. Compared to the virus-negative asymptomatic condition, children with severe colds (symptom score ≥5) showed reduced forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75), higher nasal mRNA expression of C-X-C motif chemokine ligand (CXCL)-10 and melanoma differentiation-associated protein 5, and higher protein abundance of CXCL8, CXCL10 and C-C motif chemokine ligands (CCL)-2, CCL4, CCL20 and CCL24. Children with mild (symptom score 1–4) and asymptomatic infections showed normal airway function and fewer biomarker elevations. Virus-negative cold-like illnesses demonstrated increased FeNO, minimal biomarker elevation and normal airflow. RV copy number was associated with nasal chemokine levels but not symptom score. CONCLUSION: Urban asthmatic children with high-symptom respiratory viral infections have reduced FEF25–75 and more elevations of nasal biomarkers than children with mild or asymptomatic infections, or virus-negative illnesses.
has issue date	2019-02-01(xsd:dateTime)
bibo:doi	10.1016/j.anai.2018.10.021
bibo:pmid	30385348
has license	green-oa
sha1sum (hex)	7671df838f978a12b1cf45e324085c22c3a98d0e
schema:url	https://doi.org/10.1016/j.anai.2018.10.021
resource representing a document's title	Impact of community respiratory viral infections in urban children with asthma
has PubMed Central identifier	PMC6360098
has PubMed identifier	30385348
schema:publication	Annals of Allergy, Asthma & Immunology
resource representing a document's body	covid:7671df838f978a12b1cf45e324085c22c3a98d0e#body_text
is schema:about of	named entity 'self-reported' named entity 'chemokine' named entity 'aspirates' named entity 'melanoma' named entity 'respiratory illnesses' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software