About: During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk

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About: During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk
Creator	Rivera, Amariliz Luster, Andrew Hohl, Tobias Aufiero, Mariano Espinosa, Vanessa »more»
topic	covid:73c202b1235317b5b91c64717b71c5f9344cfbb4#this
source	Elsevier; Medline; PMC
abstract	Aspergillus fumigatus, a ubiquitous mold, is a common cause of invasive aspergillosis (IA) in immunocompromised patients. Host defense against IA relies on lung-infiltrating neutrophils and monocyte-derived dendritic cells (Mo-DCs). Here, we demonstrate that plasmacytoid dendritic cells (pDCs), which are prototypically antiviral cells, participate in innate immune crosstalk underlying mucosal antifungal immunity. Aspergillus-infected murine Mo-DCs and neutrophils recruited pDCs to the lung by releasing the CXCR3 ligands, CXCL9 and CXCL10, in a Dectin-1 and Card9- and type I and III interferon signaling-dependent manner, respectively. During aspergillosis, circulating pDCs entered the lung in response to CXCR3-dependent signals. Via targeted pDC ablation, we found that pDCs were essential for host defense in the presence of normal neutrophil and Mo-DC numbers. Although interactions between pDC and fungal cells were not detected, pDCs regulated neutrophil NADPH oxidase activity and conidial killing. Thus, pDCs act as positive feedback amplifiers of neutrophil effector activity against inhaled mold conidia.
has issue date	2020-06-01(xsd:dateTime)
bibo:doi	10.1016/j.chom.2020.05.002
bibo:pmid	32485165
has license	no-cc
sha1sum (hex)	73c202b1235317b5b91c64717b71c5f9344cfbb4
schema:url	https://doi.org/10.1016/j.chom.2020.05.002
resource representing a document's title	During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk
has PubMed Central identifier	PMC7263227
has PubMed identifier	32485165
schema:publication	Cell Host Microbe
resource representing a document's body	covid:73c202b1235317b5b91c64717b71c5f9344cfbb4#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/73c202b1235317b5b91c64717b71c5f9344cfbb4
is schema:about of	named entity 'mold' named entity 'response' named entity 'immunocompromised' named entity 'Infected' named entity 'host defense' »more»

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