About: High Prevalence of Anelloviruses in Vitreous Fluid of Children With Seasonal Hyperacute Panuveitis

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About: High Prevalence of Anelloviruses in Vitreous Fluid of Children With Seasonal Hyperacute Panuveitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	High Prevalence of Anelloviruses in Vitreous Fluid of Children With Seasonal Hyperacute Panuveitis
Creator	Osterhaus, Albert Smits, Saskia Verjans, Georges Van Leeuwen, Marije Dorrestijn, Netty »more»
source	Medline; PMC
abstract	Seasonal hyperacute panuveitis (SHAPU) is a potentially blinding ocular disease occurring in Nepal that principally affects young children. Random amplification of partially purified vitreous fluid (VF)–derived nucleic acid revealed the presence of human anelloviruses in VF of SHAPU patients. In a comparative study of patients with different ocular pathologies, SHAPU patients were at highest risk of harboring anelloviruses in their eyes. The majority of SHAPU patients had multiple anelloviruses in their VF. The ocular anellovirus load in SHAPU and non-SHAPU patients did not differ and no SHAPU-specific anellovirus variant was detected. Analysis of paired serum and VF samples from SHAPU and non-SHAPU patients showed that the anellovirus detected in VF samples most likely originated from the systemic viral pool during viremia, potentially through breakdown of the blood-ocular barrier. The detection of anelloviruses in VF samples of uveitis patients, profoundly so in SHAPU patients, is imperative and warrants elucidation of its clinical significance.
has issue date	2012-06-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jis284
bibo:pmid	22492851
has license	no-cc
sha1sum (hex)	6e7eeeb52aaa159588050577530502dad2fcc5e1
schema:url	https://doi.org/10.1093/infdis/jis284
resource representing a document's title	High Prevalence of Anelloviruses in Vitreous Fluid of Children With Seasonal Hyperacute Panuveitis
has PubMed Central identifier	PMC7107317
has PubMed identifier	22492851
schema:publication	J Infect Dis
resource representing a document's body	covid:6e7eeeb52aaa159588050577530502dad2fcc5e1#body_text
is schema:about of	named entity 'ocular' named entity 'patients' named entity 'derived' named entity 'ocular' named entity 'Children' »more»

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