About: Suppressive myeloid cells are a hallmark of severe COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Suppressive myeloid cells are a hallmark of severe COVID-19
Creator	Hocke, Andreas Goffinet, Christine Volk, Hans-Dieter Zhang, Bowen Mei, Henrik »more»
source	MedRxiv
abstract	'Severe Acute Respiratory Syndrome - Coronavirus-2' (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract infection in the majority of patients. A subset of patients, however, progresses to severe disease and respiratory failure with acute respiratory distress syndrome (ARDS). Severe COVID-19 has been associated with increased neutrophil counts and dysregulated immune responses. The mechanisms of protective immunity in mild forms and the pathogenesis of dysregulated inflammation in severe courses of COVID-19 remain largely unclear. Here, we combined two single-cell RNA-sequencing technologies and single-cell proteomics in whole blood and peripheral blood mononuclear cells (PBMC) to determine changes in immune cell composition and activation in two independent dual-center patient cohorts (n=46 + n=54 COVID-19 samples), each with mild and severe cases of COVID-19. We observed a specific increase of HLA-DR high CD11c high inflammatory monocytes that displayed a strong interferon (IFN)-stimulated gene signature in patients with mild COVID-19, which was absent in severe disease. Instead, we found evidence of emergency myelopoiesis, marked by the occurrence of immunosuppressive pre-neutrophils and immature neutrophils and populations of dysfunctional and suppressive mature neutrophils, as well as suppressive HLA-DR low monocytes in severe COVID-19. Our study provides detailed insights into systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the peripheral myeloid cell compartment associated with severe courses of COVID-19.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1101/2020.06.03.20119818
has license	medrxiv
sha1sum (hex)	6d84d073a91bcb347f8bc69ed1056680529e146c
schema:url	https://doi.org/10.1101/2020.06.03.20119818
resource representing a document's title	Suppressive myeloid cells are a hallmark of severe COVID-19
resource representing a document's body	covid:6d84d073a91bcb347f8bc69ed1056680529e146c#body_text
is schema:about of	named entity 'protein' named entity 'Seurat' named entity 'scRNA-seq' named entity 'PBMC' named entity 'IL1R2' »more»

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