About: Measles Virus Glycoprotein Complex Assembly, Receptor Attachment, and Cell Entry

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About: Measles Virus Glycoprotein Complex Assembly, Receptor Attachment, and Cell Entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Measles Virus Glycoprotein Complex Assembly, Receptor Attachment, and Cell Entry
Creator	Griffin, D Oldstone, M Cattaneo, R Leonard, V Navaratnarajah, C
source	Medline; PMC
abstract	Measles virus (MV) enters cells by membrane fusion at the cell surface at neutral pH. Two glycoproteins mediate this process: the hemagglutinin (H) and fusion (F) proteins. The H-protein binds to receptors, while the F-protein mediates fusion of the viral and cellular membranes. H naturally interacts with at least three different receptors. The wild-type virus primarily uses the signaling lymphocyte activation molecule (SLAM, CD150) expressed on certain lymphatic cells, while the vaccine strain has gained the ability to also use the ubiquitous membrane cofactor protein (MCP, CD46), a regulator of complement activation. Additionally, MV infects polarized epithelial cells through an unidentified receptor (EpR). The footprints of the three receptors on H have been characterized, and the focus of research is shifting to the characterization of receptor-specific conformational changes that occur in the H-protein dimer and how these are transmitted to the F-protein trimer. It was also shown that MV attachment and cell entry can be readily targeted to designated receptors by adding specificity determinants to the H-protein. These studies have contributed to our understanding of membrane fusion by the glycopro-tein complex of paramyxoviruses in general.
has issue date	2009-01-01(xsd:dateTime)
bibo:doi	10.1007/978-3-540-70523-9_4
bibo:pmid	19198562
has license	no-cc
sha1sum (hex)	6c94dfb961870b90a0f955aa4bd64ada33dd9cfd
schema:url	https://doi.org/10.1007/978-3-540-70523-9_4
resource representing a document's title	Measles Virus Glycoprotein Complex Assembly, Receptor Attachment, and Cell Entry
has PubMed Central identifier	PMC7121846
has PubMed identifier	19198562
schema:publication	Measles
resource representing a document's body	covid:6c94dfb961870b90a0f955aa4bd64ada33dd9cfd#body_text
is schema:about of	named entity 'attachment' named entity 'CHARACTERIZATION' named entity 'ABILITY TO' named entity 'HEMAGGLUTININ' named entity 'REGULATOR' »more»

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