About: Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection
Creator	Zhang, Yan Hu, Longfei Zhou, Jian Cai, Jiabin Chai, Xiaoqiang »more»
source	BioRxiv; MedRxiv
abstract	A newly identified coronavirus, 2019-nCoV, has been posing significant threats to public health since December 2019. ACE2, the host cell receptor for severe acute respiratory syndrome coronavirus (SARS), has recently been demonstrated in mediating 2019-nCoV infection. Interestingly, besides the respiratory system, substantial proportion of SARS and 2019-nCoV patients showed signs of various degrees of liver damage, the mechanism and implication of which have not yet been determined. Here, we performed an unbiased evaluation of cell type specific expression of ACE2 in healthy liver tissues using single cell RNA-seq data of two independent cohorts, and identified specific expression in cholangiocytes. The results indicated that virus might directly bind to ACE2 positive cholangiocytes but not necessarily hepatocytes. This finding suggested the liver abnormalities of SARS and 2019-nCoV patients may not be due to hepatocyte damage, but cholangiocyte dysfunction and other causes such as drug induced and systemic inflammatory response induced liver injury. Our findings indicate that special care of liver dysfunction should be installed in treating 2019-nCoV patients during the hospitalization and shortly after cure.
has issue date	2020-02-04(xsd:dateTime)
bibo:doi	10.1101/2020.02.03.931766
has license	biorxiv
sha1sum (hex)	6c91b00faa16142426820016ad3a7847fc77c8e4
schema:url	https://doi.org/10.1101/2020.02.03.931766
resource representing a document's title	Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection
schema:publication	bioRxiv
resource representing a document's body	covid:6c91b00faa16142426820016ad3a7847fc77c8e4#body_text
is schema:about of	named entity 'cholangiocytes' named entity 'expression' named entity 'hepatocytes' named entity 'Expression' named entity 'Cholangiocytes' »more»

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