About: Memory T-cell competition for bone marrow seeding

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Memory T-cell competition for bone marrow seeding
Creator	Santoni, Angela Di, Francesca
source	Medline; PMC
abstract	The presence in the bone marrow of memory CD8 T cells is well recognized. However, it is still largely unclear how T-cell migration from the lymphoid periphery to the bone marrow is regulated. In the present report, we show that antigen-specific CD4 T cells, as well as antigen-specific CD8 T cells, localize to the bone marrow of immunized mice, and are sustained there over long periods of time. To investigate the rules governing T-cell migration to the bone marrow, we generated chimeric mice in which the lymphoid periphery contained two genetically or phenotypically distinct groups of T cells, one of which was identical to the host. We then examined whether a distinct type of T cell had an advantage over the others in the colonization of bone marrow. Our results show that whereas ICAM1 and CD18 molecules are both involved in homing to lymph nodes, neither is crucial for T-cell bone marrow colonization. We also observed that memory-phenotype CD44(high) T cells, but not virgin-type CD44(−/low) T cells, preferentially home to the bone marrow upon adoptive transfer to normal young mice, but not to thymectomized old recipients where an existing memory T-cell pool precludes their free access. Thus, T-cell colonization of the bone marrow uses distinct molecules from those implicated in lymph node homing, and is regulated both by the properties of the T cell and by the competitive efficacy of other T cells inhabiting the same, saturable niche. This implies that the homing potential of an individual lymphocyte is not merely an intrinsic property of the cell, but rather a property of the lymphoid system taken as a whole.
has issue date	2003-03-01(xsd:dateTime)
bibo:doi	10.1046/j.1365-2567.2003.01593.x
bibo:pmid	12603595
has license	green-oa
sha1sum (hex)	6c6adff0ada1e274998155234a1f05fe372040b3
schema:url	https://doi.org/10.1046/j.1365-2567.2003.01593.x
resource representing a document's title	Memory T-cell competition for bone marrow seeding
has PubMed Central identifier	PMC1782895
has PubMed identifier	12603595
schema:publication	Immunology
resource representing a document's body	covid:6c6adff0ada1e274998155234a1f05fe372040b3#body_text
is schema:about of	named entity 'observed' named entity 'bone marrow' named entity 'time' named entity 'competitive' named entity 'T-CELL' »more»

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