About: Evidence of MAPK–JNK1/2 activation by hepatitis E virus ORF3 protein in cultured hepatoma cells

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About: Evidence of MAPK–JNK1/2 activation by hepatitis E virus ORF3 protein in cultured hepatoma cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evidence of MAPK–JNK1/2 activation by hepatitis E virus ORF3 protein in cultured hepatoma cells
Creator	Khalid Parvez, Mohammad Al-Dosari, Salem Mohammed, •
source	Medline; PMC
abstract	Hepatitis E virus (HEV) has recently emerged to cause chronic infection in some immunosuppressed individuals, including extrahepatic manifestations in acute and chronic patients. Mammalian MAPK–JNK1/2 is expressed in hepatocytes, which is known to be involved in anti-apoptotic signaling pathway for the establishment of persistent infection. Though in vitro modulation of cellular MAPK–ERK cascade by HEV-ORF3 protein is suggested to have a role in host pathobiology, activation of the JNK module has not been studied so far. In this report, we have shown for the first time, evidence of MAPK–JNK1/2 activation by HEV-ORF3, using viral replicon as well as expression vector in human hepatoma cells. Phospho-ELISA based relative quantitaion has demonstrated ~54% and ~66% phosphorylation of JNK1/2 in replicon-RNA and ORF3-vector DNA transfected cells, respectively. Our finding however, suggests further molecular studies to validate a role of JNK1/2 in HEV pathogenesis.
has issue date	2014-10-04(xsd:dateTime)
bibo:doi	10.1007/s10616-014-9785-1
bibo:pmid	25280525
has license	green-oa
sha1sum (hex)	6b4f22d6788402377d45bb1c0bd8882d8023f376
schema:url	https://doi.org/10.1007/s10616-014-9785-1
resource representing a document's title	Evidence of MAPK–JNK1/2 activation by hepatitis E virus ORF3 protein in cultured hepatoma cells
has PubMed Central identifier	PMC4371560
has PubMed identifier	25280525
schema:publication	Cytotechnology
resource representing a document's body	covid:6b4f22d6788402377d45bb1c0bd8882d8023f376#body_text
is schema:about of	named entity 'expressed' named entity 'STUDIES' named entity 'FAR' named entity 'HEPATITIS E VIRUS' named entity 'ORF3' »more»

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