About: ACE2-expressing endothelial cells in aging mouse brain

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	ACE2-expressing endothelial cells in aging mouse brain
Creator	Dawson, Ted Dawson, Valina Lim, Su Kang, Sung-Ung
source	BioRxiv
abstract	Angiotensin-converting enzyme 2 (ACE2) is a key receptor mediating the entry of SARS-CoV-2 into the host cell. Through a systematic analysis of publicly available mouse brain sc/snRNA-seq data, we found that ACE2 is specifically expressed in small sub-populations of endothelial cells and mural cells, namely pericytes and vascular smooth muscle cells. Further, functional changes in viral mRNA transcription and replication, and impaired blood-brain barrier regulation were most prominently implicated in the aged, ACE2-expressing endothelial cells, when compared to the young adult mouse brains. Concordant EC transcriptomic changes were further found in normal aged human brains. Overall, this work reveals an outline of ACE2 distribution in the mouse brain and identify putative brain host cells that may underlie the selective susceptibility of the aging brain to viral infection.
has issue date	2020-07-11(xsd:dateTime)
bibo:doi	10.1101/2020.07.11.198770
has license	biorxiv
sha1sum (hex)	6884f051da7ffca937304d2b6296fbbb9ec7c655
schema:url	https://doi.org/10.1101/2020.07.11.198770
resource representing a document's title	ACE2-expressing endothelial cells in aging mouse brain
schema:publication	bioRxiv
resource representing a document's body	covid:6884f051da7ffca937304d2b6296fbbb9ec7c655#body_text
is schema:about of	named entity 'endothelial cells' named entity 'distribution' named entity 'expressing' named entity 'AVAILABLE' named entity 'PERICYTES' »more»

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