About: Differential Seroprevalence of Human Bocavirus Species 1-4 in Beijing, China

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About: Differential Seroprevalence of Human Bocavirus Species 1-4 in Beijing, China Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Differential Seroprevalence of Human Bocavirus Species 1-4 in Beijing, China
Creator	Hung, Tao Li, Jianguo Vernet, Guy Wang, Jianwei Zhou, Hongli »more»
source	PMC
abstract	BACKGROUND: Four species of human bocaviruses (HBoV1-4) have been identified based on phylogenetic analysis since its first report in 2005. HBoV1 has been associated with respiratory disease, whereas HBoV2-4 are mainly detected in enteric infections. Although the prevalence of HBoVs in humans has been studied in some regions, it has not been well addressed globally. METHODOLOGY/PRINCIPAL FINDINGS: Cross-reactivity of anti-VP2 antibodies was detected between HBoV1, 2, 3, and 4 in mouse and human serum. The prevalence of specific anti-VP2 IgG antibodies against HBoV1-4 was determined in different age groups of healthy individuals aged 0-70 years old in Beijing, China, using a competition ELISA assay based on virus-like particles of HBoV1-4. The seroprevalence of HBoV1-4 was 50%, 36.9%, 28.7%, and 0.8%, respectively, in children aged 0-14 years (n = 244); whereas the seroprevalence of HBoV1-4 was 66.9%, 49.3%, 38.7% and 1.4%, respectively, in healthy adults (≥15 years old; n = 142). The seropositive rate of HBoV1 was higher than that of HBoV2, HBoV3, and HBoV4 in individuals older than 0.5 years. Furthermore, IgG seroconversion of HBoV1 (10/31, 32.3%), HBoV2 (8/31, 25.8%), and HBoV3 (2/31, 6.5%) was found in paired sera collected from children with respiratory tract infections who were positive for HBoV1 according to PCR analysis. CONCLUSIONS/SIGNIFICANCE: Our data indicate that HBoV1 is more prevalent than HBoV2, HBoV3, and HBoV4 in the population we sampled in Beijing, China, suggesting that HBoV species may play differential roles in disease.
has issue date	2012-06-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0039644
bibo:pmid	22761854
has license	cc-by
sha1sum (hex)	687dd2bd2a0f74f0ef9383f75fb1147e28dfe1d6
schema:url	https://doi.org/10.1371/journal.pone.0039644
resource representing a document's title	Differential Seroprevalence of Human Bocavirus Species 1-4 in Beijing, China
has PubMed Central identifier	PMC3382199
has PubMed identifier	22761854
schema:publication	PLoS One
resource representing a document's body	covid:687dd2bd2a0f74f0ef9383f75fb1147e28dfe1d6#body_text
is schema:about of	named entity 'SEROPREVALENCE' named entity 'BEIJING' named entity 'HUMANS' named entity 'PHYLOGENETIC ANALYSIS' named entity 'RESPIRATORY DISEASE' »more»

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