About: Adhesion molecules in pediatric intensive care patients with organ dysfunction syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Adhesion molecules in pediatric intensive care patients with organ dysfunction syndrome
Creator	Heinzmann, Andrea Krueger, Marcus Nauck, Markus Heinzmann, · Krueger, M »more»
source	PMC
abstract	OBJECTIVE: To determine serum concentrations of the soluble forms of vascular cell adhesion molecule 1 (VCAM-1), intracellular adhesion molecule 1 (ICAM-1), and E-selectin in ventilated neonatal and pediatric intensive care patients with varying severity of multiorgan dysfunction syndrome (MODS) with or without infection-triggered organ failure. DESIGN AND SETTING: Prospective pilot study, a level III neonatal and pediatric intensive care unit at a University children's Hospital. PATIENTS: We studied 22 ventilated pediatric (n = 15) and neonatal (n = 7) intensive care patients (aged 3 days–16 years). Inclusion criteria were mechanical ventilation and signs of at least one additional organ dysfunction (cardiovascular, respiratory, neurological, hematological, or renal). MEASUREMENTS AND RESULTS: Serum concentrations of the adhesion molecules were analyzed on the day of maximum organ dysfunction score and were quantitated by a sandwich ELISA technique. The overall mortality rate was 36% (8/22). Dysfunction of three or more organ systems was defined as MODS and was associated with a significant increase in VCAM-1 serum levels relative to dysfunction of three or fewer organ systems [median 1239 ng/ml (IQR 928–1615) vs. 766 ng/ml (644–915)]. A significant difference in E-selectin serum levels was found between organ failure of infectious (median 131 ng/ml, IQR 112–146) and noninfectious origin (68 ng/ml 49–105). CONCLUSIONS: Determination of adhesion molecules in pediatric intensive care patients raises the possibility of more specific pathophysiological understanding. E-selectin showed significantly different serum levels between infectious and noninfectious causes of organ failure.
has issue date	2006-11-24(xsd:dateTime)
bibo:doi	10.1007/s00134-006-0453-6
bibo:pmid	17124613
has license	no-cc
sha1sum (hex)	66eed2fcc3c3a1752be613160928d590c512af98
schema:url	https://doi.org/10.1007/s00134-006-0453-6
resource representing a document's title	Adhesion molecules in pediatric intensive care patients with organ dysfunction syndrome
has PubMed Central identifier	PMC7095409
has PubMed identifier	17124613
schema:publication	Intensive Care Med
resource representing a document's body	covid:66eed2fcc3c3a1752be613160928d590c512af98#body_text
is schema:about of	named entity 'MODS' named entity 'E-selectin' named entity 'Patients' named entity 'Adhesion' named entity 'MEASUREMENTS' »more»

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