About: Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

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About: Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
Creator	Peiris, Malik Zheng, Bojian Poon, Leo Chan, Kwok-Hung Chen, Yongxiong »more»
source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV–infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/ng1698) contains supplementary material, which is available to authorized users.
has issue date	2005-12-20(xsd:dateTime)
bibo:doi	10.1038/ng1698
bibo:pmid	16369534
has license	no-cc
sha1sum (hex)	64ebccae746f7f91b7254d4b842984dd4f8ffee4
schema:url	https://doi.org/10.1038/ng1698
resource representing a document's title	Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
has PubMed Central identifier	PMC7097088
has PubMed identifier	16369534
schema:publication	Nat Genet
resource representing a document's body	covid:64ebccae746f7f91b7254d4b842984dd4f8ffee4#body_text
is schema:about of	named entity 'risk' named entity 'Severe acute respiratory syndrome (SARS)' named entity 'higher' named entity 'individuals' named entity 'LUNG' »more»

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