About: Drug repurposing screens reveal FDA approved drugs active against SARS-Cov-2

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Drug repurposing screens reveal FDA approved drugs active against SARS-Cov-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Drug repurposing screens reveal FDA approved drugs active against SARS-Cov-2
Creator	Li, Minghua Cherry, Sara Lee, Jae Dittmar, Mark Jurado, Kellie »more»
source	BioRxiv
abstract	There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. To identify new candidates we screened a repurposing library of ~3,000 drugs. Screening in Vero cells found few antivirals, while screening in human Huh7.5 cells validated 23 diverse antiviral drugs. Extending our studies to lung epithelial cells, we found that there are major differences in drug sensitivity and entry pathways used by SARS-CoV-2 in these cells. Entry in lung epithelial Calu-3 cells is pH-independent and requires TMPRSS2, while entry in Vero and Huh7.5 cells requires low pH and triggering by acid-dependent endosomal proteases. Moreover, we found 9 drugs are antiviral in lung cells, 7 of which have been tested in humans, and 3 are FDA approved including Cyclosporine which we found is targeting Cyclophilin rather than Calcineurin for its antiviral activity. These antivirals reveal essential host targets and have the potential for rapid clinical implementation.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1101/2020.06.19.161042
has license	biorxiv
sha1sum (hex)	63071296fcf911324bbe22bc97e2c0117911071a
schema:url	https://doi.org/10.1101/2020.06.19.161042
resource representing a document's title	Drug repurposing screens reveal FDA approved drugs active against SARS-Cov-2
schema:publication	bioRxiv
resource representing a document's body	covid:63071296fcf911324bbe22bc97e2c0117911071a#body_text
is schema:about of	named entity 'cells' named entity 'antivirals' named entity 'cells' named entity 'cells' named entity 'library' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software