About: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus

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About: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
Creator	Chen, Ting Yuan, Jing Liu, Jiangning Qin, Chuan Xu, Yanfeng »more»
source	PMC
abstract	BACKGROUND: The current study was conducted to establish animal models (including mouse and ferret) for the novel avian-origin H7N9 influenza virus. FINDINGS: A/Anhui/1/2013 (H7N9) virus was administered by intranasal instillation to groups of mice and ferrets, and animals developed typical clinical signs including body weight loss (mice and ferrets), ruffled fur (mice), sneezing (ferrets), and death (mice). Peak virus shedding from respiratory tract was observed on 2 days post inoculation (d.p.i.) for mice and 3–5 d.p.i. for ferrets. Virus could also be detected in brain, liver, spleen, kidney, and intestine from inoculated mice, and in heart, liver, and olfactory bulb from inoculated ferrets. The inoculation of H7N9 could elicit seroconversion titers up to 1280 in ferrets and 160 in mice. Leukopenia, significantly reduced lymphocytes but increased neutrophils were also observed in mouse and ferret models. CONCLUSIONS: The mouse and ferret model enables detailed studies of the pathogenesis of this illness and lay the foundation for drug or vaccine evaluation.
has issue date	2013-08-08(xsd:dateTime)
bibo:doi	10.1186/1743-422x-10-253
bibo:pmid	23927489
has license	cc-by
sha1sum (hex)	6243ba518b9ce9b27ea21572bd154ca6ba95f22d
schema:url	https://doi.org/10.1186/1743-422x-10-253
resource representing a document's title	The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
has PubMed Central identifier	PMC3750532
has PubMed identifier	23927489
schema:publication	Virol J
resource representing a document's body	covid:6243ba518b9ce9b27ea21572bd154ca6ba95f22d#body_text
is schema:about of	named entity 'conducted' named entity 'ORIGIN' named entity 'NOVEL' named entity 'ferret' named entity 'virus' »more»

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