About: Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists
Creator	Anderluh, Marko Obermajer, Nataša Bernardi, Anna Colombo, Cinzia Sattin, Sara »more»
source	Medline; PMC
abstract	In this article, we describe the design, synthesis and activity evaluation of glycomimetic DC-SIGN antagonists, that use a mannose residue to anchor to the protein carbohydrate recognition domain (CRD). The molecules were designed from the structure of the known pseudo-mannobioside antagonist 1, by including additional hydrophobic groups, which were expected to engage lipophilic areas of DC-SIGN CRD. The results demonstrate that the synthesized compounds potently inhibit DC-SIGN-mediated adhesion to mannan coated plates. Additionally, in silico docking studies were performed to rationalize the results and to suggest further optimization. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11030-010-9285-y) contains supplementary material, which is available to authorized users.
has issue date	2010-11-14(xsd:dateTime)
bibo:doi	10.1007/s11030-010-9285-y
bibo:pmid	21076980
has license	no-cc
sha1sum (hex)	61e8d5669985ccd4a45577e0681b71d1653b0a36
schema:url	https://doi.org/10.1007/s11030-010-9285-y
resource representing a document's title	Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists
has PubMed Central identifier	PMC7089406
has PubMed identifier	21076980
schema:publication	Mol Divers
resource representing a document's body	covid:61e8d5669985ccd4a45577e0681b71d1653b0a36#body_text
is schema:about of	named entity 'ANTAGONISTS' named entity 'BASED' named entity 'performed' named entity 'additional' named entity 'demonstrate' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software