About: Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

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About: Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome
Creator	Molenkamp, Richard Koopmans, Marion Sette, Alessandro Haagmans, Bart Grifoni, Alba »more»
source	MedRxiv
abstract	COVID-19 is associated with lymphopenia and cytokine storm, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, we characterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory distress syndrome. The spike protein (S) proved a potent T-cell antigen and specific T-cells predominantly produced Th1 cytokines. These novel data are important in vaccine design and will facilitate evaluation of vaccine candidate immunogenicity.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1101/2020.04.11.20062349
has license	medrxiv
sha1sum (hex)	614d785e21ecdf42b362d8d7f42c23422b6290ab
schema:url	https://doi.org/10.1101/2020.04.11.20062349
resource representing a document's title	Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome
resource representing a document's body	covid:614d785e21ecdf42b362d8d7f42c23422b6290ab#body_text
is schema:about of	named entity 'vaccine' named entity 'antigen' named entity 'SARS-CoV-2' named entity 'CD4' named entity 'protein' »more»

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