About: The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells

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About: The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells
Creator	Zhu, Guoqiang Zhu, Liqian Qi, Yanhua Jiang, Xinyi Fu, Xiaotian
source	Medline; PMC
abstract	During bovine herpesvirus 1 (BoHV-1) productive infection in cell cultures, partial of intranuclear viral DNA is present in nucleosomes, and viral protein VP22 associates with histones and decreases histone H4 acetylation, indicating the involvement of histone H4 acetylation in virus replication. In this study, we demonstrated that BoHV-1 infection at the late stage (at 24 h after infection) dramatically decreased histone H3 acetylation [at residues K9 (H3K9ac) and K18 (H3K18ac)], which was supported by the pronounced depletion of histone acetyltransferases (HATs) including CBP/P300 (CREB binding protein and p300), GCN5L2 (general control of amino acid synthesis yeast homolog like 2) and PCAF (P300/CBP-associated factor). The depletion of GCN5L2 promoted by virus infection was partially mediated by ubiquitin-proteasome pathway. Interestingly, the viral replication was enhanced by HAT (histone acetyltransferase) activator CTPB [N-(4-Chloro-3-trifluoromethylphenyl)-2-ethoxy-6-pentadecylbenzamide], and vice versa, inhibited by HAT inhibitor Anacardic acid (AA), suggesting that BoHV-1 may take advantage of histone acetylation for efficient replication. Taken together, we proposed that the HAT-dependent histone H3 acetylation plays an important role in BoHV-1 replication in MDBK (Madin-Darby bovine kidney) cells.
has issue date	2018-09-27(xsd:dateTime)
bibo:doi	10.3390/v10100525
bibo:pmid	30261679
has license	cc-by
sha1sum (hex)	6056a0e443703a9fddcd11fd969f5d3cd78ea9da
schema:url	https://doi.org/10.3390/v10100525
resource representing a document's title	The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells
has PubMed Central identifier	PMC6213513
has PubMed identifier	30261679
schema:publication	Viruses
resource representing a document's body	covid:6056a0e443703a9fddcd11fd969f5d3cd78ea9da#body_text
is schema:about of	named entity 'P300' named entity 'plays' covid:arg/6056a0e443703a9fddcd11fd969f5d3cd78ea9da named entity 'demonstrated' named entity 'histone acetyltransferase' »more»

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