About: Master Regulator Analysis of the SARS-CoV-2/Human interactome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Master Regulator Analysis of the SARS-CoV-2/Human interactome
Creator	Ceraolo, Carmine Guzzi, Pietro Giorgi, Federico Mercatelli, Daniele
source	BioRxiv
abstract	the recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 and causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
has issue date	2020-03-17(xsd:dateTime)
bibo:doi	10.1101/2020.03.15.992925
has license	biorxiv
sha1sum (hex)	5ea6646810fece4bb4dd1de2f613ddd3afcab9ed
schema:url	https://doi.org/10.1101/2020.03.15.992925
resource representing a document's title	Master Regulator Analysis of the SARS-CoV-2/Human interactome
schema:publication	bioRxiv
resource representing a document's body	covid:5ea6646810fece4bb4dd1de2f613ddd3afcab9ed#body_text
is schema:about of	named entity 'coronavirus' named entity 'current' named entity 'virus' named entity 'develop' named entity 'notions' »more»

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