About: Application of Genetically Engineered Pigs in Biomedical Research

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Application of Genetically Engineered Pigs in Biomedical Research
Creator	Hryhorowicz, Magdalena Hryhorowicz, Szymon Lipiński, Daniel Nowak-Terpiłowska, Agnieszka Ryczek, Natalia »more»
topic	covid:5e84aeca287c142b59769c6409b6fa72361c844a#this
source	Medline; PMC
abstract	Progress in genetic engineering over the past few decades has made it possible to develop methods that have led to the production of transgenic animals. The development of transgenesis has created new directions in research and possibilities for its practical application. Generating transgenic animal species is not only aimed towards accelerating traditional breeding programs and improving animal health and the quality of animal products for consumption but can also be used in biomedicine. Animal studies are conducted to develop models used in gene function and regulation research and the genetic determinants of certain human diseases. Another direction of research, described in this review, focuses on the use of transgenic animals as a source of high-quality biopharmaceuticals, such as recombinant proteins. The further aspect discussed is the use of genetically modified animals as a source of cells, tissues, and organs for transplantation into human recipients, i.e., xenotransplantation. Numerous studies have shown that the pig (Sus scrofa domestica) is the most suitable species both as a research model for human diseases and as an optimal organ donor for xenotransplantation. Short pregnancy, short generation interval, and high litter size make the production of transgenic pigs less time-consuming in comparison with other livestock species This review describes genetically modified pigs used for biomedical research and the future challenges and perspectives for the use of the swine animal models.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.3390/genes11060670
bibo:pmid	32575461
has license	cc-by
sha1sum (hex)	5e84aeca287c142b59769c6409b6fa72361c844a
schema:url	https://doi.org/10.3390/genes11060670
resource representing a document's title	Application of Genetically Engineered Pigs in Biomedical Research
has PubMed Central identifier	PMC7349405
has PubMed identifier	32575461
schema:publication	Genes (Basel)
resource representing a document's body	covid:5e84aeca287c142b59769c6409b6fa72361c844a#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/5e84aeca287c142b59769c6409b6fa72361c844a
is schema:about of	named entity 'accelerating' named entity 'transgenic animals' named entity 'Progress' named entity 'develop' named entity 'aspect' »more»

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