About: Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection
Creator	Qin, Kai Kobie, James Bansal, Anju Long, Dustin Boppana, Sushma »more»
source	MedRxiv
abstract	SARS-CoV-2 causes a wide spectrum of clinical manifestations and significant mortality. Studies investigating underlying immune characteristics are needed to understand disease pathogenesis and inform vaccine design. In this study, we examined immune cell subsets in hospitalized and non-hospitalized individuals. In hospitalized patients, many adaptive and innate immune cells were decreased in frequency compared to healthy and convalescent individuals, with the exception of B lymphocytes which increased. Our findings show increased frequencies of T-cell activation markers (CD69, Ox40, HLA-DR and CD154) in hospitalized patients, with other T-cell activation/exhaustion markers (CD25, PD-L1 and TIGIT) remaining elevated in hospitalized and non-hospitalized individuals. B cells had a similar pattern of activation/exhaustion, with increased frequency of CD69 and CD95 during hospitalization, followed by an increase in PD1 frequencies in non-hospitalized individuals. Interestingly, many of these changes were found to increase over time in non-hospitalized longitudinal samples, suggesting a prolonged period of immune dysregulation following SARS-CoV-2 infection. Changes in T-cell activation/exhaustion in non-hospitalized patients were found to positively correlate with age. Severely infected individuals had increased expression of activation and exhaustion markers. These data suggest a prolonged period of immune dysregulation following SARS-CoV-2 infection highlighting the need for additional studies investigating immune dysregulation in convalescent individuals.
has issue date	2020-08-01(xsd:dateTime)
bibo:doi	10.1101/2020.07.30.20165175
has license	medrxiv
sha1sum (hex)	5db99dbe579c42a2db906f7cd58c940c430eb3fa
schema:url	https://doi.org/10.1101/2020.07.30.20165175
resource representing a document's title	Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection
resource representing a document's body	covid:5db99dbe579c42a2db906f7cd58c940c430eb3fa#body_text
is schema:about of	named entity 'license' named entity 'activation' named entity 'adaptive' named entity 'population' named entity 'Studies' »more»

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