About: Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia
Creator	Lear, Travis Birru, Rahel Chen, Bill Coon, Tiffany Leikauf, George »more»
source	PMC
abstract	Cyclic adenosine monophosphate (cAMP) is a crucial intracellular second messenger molecule that converts extracellular molecules to intracellular signal transduction pathways generating cell- and stimulus-specific effects. Importantly, specific phosphodiesterase (PDE) subtypes control the amplitude and duration of cAMP-induced physiological processes and are therefore a prominent pharmacological target currently used in a variety of fields. Here we tested the extracts from traditional Chinese medicine, Forsythia suspense seeds, which have been used for more than 2000 years to relieve respiratory symptoms. Using structural-functional analysis we found its major lignin, Forsynthin, acted as an immunosuppressant by inhibiting PDE4 in inflammatory and immune cell. Moreover, several novel, selective small molecule derivatives of Forsythin were tested in vitro and in murine models of viral and bacterial pneumonia, sepsis and cytokine-driven systemic inflammation. Thus, pharmacological targeting of PDE4 may be a promising strategy for immune-related disorders characterized by amplified host inflammatory response.
has issue date	2014-12-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0115937
bibo:pmid	25549252
has license	cc-by
sha1sum (hex)	5d7ef1b6d6d20f3a2d0c1cad4daa1496ef8a195b
schema:url	https://doi.org/10.1371/journal.pone.0115937
resource representing a document's title	Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia
has PubMed Central identifier	PMC4280171
has PubMed identifier	25549252
schema:publication	PLoS One
resource representing a document's body	covid:5d7ef1b6d6d20f3a2d0c1cad4daa1496ef8a195b#body_text
is schema:about of	named entity 'lignin' named entity 'Novel' named entity 'FORSYTHIA' named entity 'PDE4 INHIBITORS' named entity 'DERIVED' »more»

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