About: A Prospective Evaluation of Real-Time PCR Assays for the Detection of Orientia tsutsugamushi and Rickettsia spp. for Early Diagnosis of Rickettsial Infections during the Acute Phase of Undifferentiated Febrile Illness

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About: A Prospective Evaluation of Real-Time PCR Assays for the Detection of Orientia tsutsugamushi and Rickettsia spp. for Early Diagnosis of Rickettsial Infections during the Acute Phase of Undifferentiated Febrile Illness Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A Prospective Evaluation of Real-Time PCR Assays for the Detection of Orientia tsutsugamushi and Rickettsia spp. for Early Diagnosis of Rickettsial Infections during the Acute Phase of Undifferentiated Febrile Illness
Creator	Turner, Paul Nosten, François Tanganuchitcharnchai, Ampai Turner, Claudia Watthanaworawit, Wanitda »more»
source	PMC
abstract	One hundred and eighty febrile patients were analyzed in a prospective evaluation of Orientia tsutsugamushi and Rickettsia spp. real-time polymerase chain reaction (PCR) assays for early diagnosis of rickettsial infections. By paired serology, 3.9% (7 of 180) and 6.1% (11 of 180) of patients were confirmed to have acute scrub or murine typhus, respectively. The PCR assays for the detection of O. tsutsugamushi and Rickettsia spp. had high specificity (99.4% [95% confidence interval (CI): 96.8–100] and 100% [95% CI: 97.8–100], respectively). The PCR results were also compared with immunoglobulin M (IgM) immunofluorescence assay (IFA) on acute sera. For O. tsutsugamushi, PCR sensitivity was twice that of acute specimen IgM IFA (28.6% versus 14.3%; McNemar's P = 0.3). For Rickettsia spp., PCR was four times as sensitive as acute specimen IgM IFA (36.4% versus 9.1%; P = 0.08), although this was not statistically significant. Whole blood and buffy coat, but not serum, were acceptable specimens for these PCRs. Further evaluation of these assays in a larger prospective study is warranted.
has issue date	2013-08-07(xsd:dateTime)
bibo:doi	10.4269/ajtmh.12-0600
bibo:pmid	23732256
has license	no-cc
sha1sum (hex)	5c5a6ea2bb2e3865e47d4495eb6ee3e4cddb1134
schema:url	https://doi.org/10.4269/ajtmh.12-0600
resource representing a document's title	A Prospective Evaluation of Real-Time PCR Assays for the Detection of Orientia tsutsugamushi and Rickettsia spp. for Early Diagnosis of Rickettsial Infections during the Acute Phase of Undifferentiated Febrile Illness
has PubMed Central identifier	PMC3741253
has PubMed identifier	23732256
schema:publication	Am J Trop Med Hyg
resource representing a document's body	covid:5c5a6ea2bb2e3865e47d4495eb6ee3e4cddb1134#body_text
is schema:about of	named entity 'EVALUATION' named entity 'paired' named entity 'Further' named entity 'high' named entity 'Diagnosis' »more»

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