About: A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes

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About: A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes
Creator	Li, Xin Zhang, Yu Deng, Mengmeng Gui, Mingming Hou, Junwei »more»
source	PMC
abstract	Cytotoxic T cells (CTLs) play a key role in the control of Hepatitis B virus (HBV) infection and viral clearance. However, most of identified CTL epitopes are derived from HBV of genotypes A and D, and few have been defined in virus of genotypes B and C which are more prevalent in Asia. As HBV core protein (HBc) is the most conservative and immunogenic component, in this study we used an overlapping 9-mer peptide pool covering HBc to screen and identify specific CTL epitopes. An unconventional HLA-A2-restricted epitope HBc141–149 was discovered and structurally characterized by crystallization analysis. The immunogenicity and anti-HBV activity were further determined in HBV and HLA-A2 transgenic mice. Finally, we show that mutations in HBc141–149 epitope are associated with viral parameters and disease progression in HBV infected patients. Our data therefore provide insights into the structure characteristics of this unconventional epitope binding to MHC-I molecules, as well as epitope specific CTL activity that orchestrate T cell response and immune evasion in HBV infected patients.
has issue date	2014-03-22(xsd:dateTime)
bibo:doi	10.1007/s13238-014-0041-4
bibo:pmid	24659387
has license	no-cc
sha1sum (hex)	5baa1d21e6334a0af38c31d852992e7e6ad2402c
schema:url	https://doi.org/10.1007/s13238-014-0041-4
resource representing a document's title	A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes
has PubMed Central identifier	PMC3978166
has PubMed identifier	24659387
schema:publication	Protein Cell
resource representing a document's body	covid:5baa1d21e6334a0af38c31d852992e7e6ad2402c#body_text
is schema:about of	named entity 'ELICITS' named entity 'peptide' named entity 'data' named entity 'insights' named entity 'identify' »more»

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