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About:
Integrating Logical Rules Into Neural Multi-Hop Reasoning for Drug Repurposing
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Academic Article
research paper
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Covid-on-the-Web dataset
title
Integrating Logical Rules Into Neural Multi-Hop Reasoning for Drug Repurposing
Creator
Hildebrandt, Marcel
Joblin, Mitchell
Liu, Yushan
Ringsquandl, Martin
Tresp, Volker
source
ArXiv
abstract
The graph structure of biomedical data differs from those in typical knowledge graph benchmark tasks. A particular property of biomedical data is the presence of long-range dependencies, which can be captured by patterns described as logical rules. We propose a novel method that combines these rules with a neural multi-hop reasoning approach that uses reinforcement learning. We conduct an empirical study based on the real-world task of drug repurposing by formulating this task as a link prediction problem. We apply our method to the biomedical knowledge graph Hetionet and show that our approach outperforms several baseline methods.
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2020-07-10
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arxiv
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589bf79968b1a789ccf883c74bf42c92c570212e
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Integrating Logical Rules Into Neural Multi-Hop Reasoning for Drug Repurposing
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