About: Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies

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About: Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies
Creator	Shoenfeld, Yehuda Fagone, Paolo Bramanti, Placido Nicoletti, Ferdinando Bendtzen, Klaus »more»
source	Elsevier; Medline; PMC
abstract	The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. The present study identified a specific set of biological pathways altered in primary human lung epithelium upon SARS-CoV-2 infection, and a comparison with SARS-CoV from the 2003 pandemic was studied. The transcriptomic profiles were also exploited as possible novel therapeutic targets, and anti-signature perturbation analysis predicted potential drugs to control disease progression. Among them, Mitogen-activated protein kinase kinase (MEK), serine-threonine kinase (AKT), mammalian target of rapamycin (mTOR) and I kappa B Kinase (IKK) inhibitors emerged as candidate drugs. Finally, sex-specific differences that may underlie the higher COVID-19 mortality in men are proposed.
has issue date	2020-05-03(xsd:dateTime)
bibo:doi	10.1016/j.autrev.2020.102571
bibo:pmid	32376402
has license	no-cc
sha1sum (hex)	5899da2830db53126c28a0c17815218b810021d0
schema:url	https://doi.org/10.1016/j.autrev.2020.102571
resource representing a document's title	Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies
has PubMed Central identifier	PMC7252184
has PubMed identifier	32376402
schema:publication	Autoimmun Rev
resource representing a document's body	covid:5899da2830db53126c28a0c17815218b810021d0#body_text
is schema:about of	named entity 'tailored' named entity 'virus' named entity 'SARS-CoV-2' named entity 'therapeutic strategies' named entity 'SARS-CoV-2' »more»

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